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Our straightforward idea for system simplification and modeling is outlining a structure based on its atomic information and using building blocks to represent the irreversible binding-site variants. Computational characterization of the binding mode in a new receptor-ligand system will be subsequently implemented. In this step, we will develop novel feature-extraction methods relying on free energy calculation and decomposition, interface shape/volume estimation and binding-site motion analysis. Examples of such computational characterizations will be shown in this project, and these characterization alternatives will lead to efficient calculations of binding affinity in a new receptor-ligand system. We will combine the alternatives into an integrated software/program suite, which can encourage users to select different models based on specific requirements or within various application scenarios. Finally, a post-analysis will be conducted for a situation where a group or crowd of system variants are involved. We will utilize well-validated methods for supervised or unsupervised learning of these system samples, and will thus make predictions of newcomers or variants. This analysis will also join the software/program suite for multi-purpose analyses or studies. Moreover, the whole software/program suite will be adapted at the end of this project, to provide compatible interfaces with other broadly-used software of molecular modeling, molecular dynamics simulations and structural analysis.
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This research aims at developing sustainable strategies for non-profit transportation organisations to provide dial-a-ride services for people with disabilities through the optimisation of revenue and resource management. As an on-demand, door-to-door transport service that requires advanced booking, DAR’s utilisation rate is usually low compared with the scheduled route services, and this operation characteristic creates a relatively high ratio of subsidy per person. To address this issue by optimising the resource management, we will study the service options of vehicle pooling arrangements in DAR operations. Through optimisation models, we will identify the relationships among discount rates, passenger tolerance of traveling time and vehicle utilisation rates for the new vehicle scheduling sustainable strategies. Such results are expected for the transportation organisations to serve more people without the demand of additional vehicles. The proliferation of online communities and social media has propelled word-of-mouth communication across cultural and national boundaries.
However, the use of GGD model for image segmentation has not been studied in the literature. Our motivation for the proposed project is to investigate a robust and effective GGD-based segmentation model for a wide range of applications. In particular, we will study the mathematical optimisation framework that integrates the GGD model https://handycasinozone.com/ with an agglomerative fuzzy algorithm with spatial information for image segmentation applications. We will also develop a rigorous mathematical analysis on the fuzzy GGD segmentation model. The performance of the proposed segmentation algorithm will be evaluated by extensive and comparative experiments on natural and texture images.
Conveniently-selected residential care services for persons with disabilities from four non-government organizations will be approached. Maximum variation convenience sampling will be used to recruit care providers from the residential care services. Direct unstructured observations for each residential care services, and audio-taped recorded vignette-based interviews are the data collection methods to be used. The findings will provide data on the types, events and interactions that can trigger off challenging behaviours for persons with intellectual disability and residential care services. Responses of the staff and their management of different types of challenging incidents and events will also be described. This study acknowledges that care providers are an asset to any organizations and focused attention should be given to address their needs and concerns when they have to confront and handle a range of challenging behaviours of persons with intellectual disability. Cocaine- and amphetamine-regulated transcript peptides are important modulators that act in the brain and contribute to a range of physiological and behavioural processes including feeding, stress, energy expenditure and body weight control. In rodents, CART peptides and their mRNAs are found in many brain regions and in peripheral tissues that are involved in reward/ enforcement, feeding and emesis, and there is strong anatomical association between CART and various orexigenic and anorexigenic neuropeptides. Acute administration of d-amphetamine, which upregulates CART mRNA in rat striatum, is anti-emetic against apomorphine-induced emesis and motion sickness.
It is worth noting that most problems in the real world are concerned with more than one objective. However, there has not been much research into sparse multi-objective optimization problems . Therefore there is a great demand to establish an in-depth theory in the optimality of SMOPs. In this project, we will investigate the sparse tri-objective quadratic programming problems and the sparse bi-objective Conditional-Value-at-Risk programming problems . For the STQPPs, we will study the optimality wealth generators review conditions and investigate the properties of the Pareto optimal solution set. We plan to use Clarke subgradient for analysis and devise effective computational algorithms for solving the STQPPs. For SBCPPs, we will consider the multi-objective convex programming method and piecewise linear approach for solving the SBCPPs. We will also conduct extensive numerical experiments to demonstrate the high efficiency of our proposed algorithm on solving bi-objective convex programming problems.
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That correlates with the theory of neo-patrimonialism, which claims that post-colonial elites used the coercive powers of the state to maintain their political positions and to increase their personal wealth. Ola Olson opposes that view by arguing that in a developing economy, the government is the only actor with the financial and political means to unify the state apparatus behind an industrialization process. In line with that economic vision, Tanzania engaged in the nationalization of industry to create jobs and to produce a domestic market for goods while it maintained an adherence to African socialist principles exemplified through the ujamaa program of villagization. The unaffordability of industrial products and increased tensions between managers and settlers of the villages contributed to a “colossal failure” of ISI in Tanzania, leading it to abandon the villagization project and to focus on agricultural development. Noble Apex contributes to the community actively, for example, in promoting appropriate financial education in the community and improving public financial management awareness. In order to further contribute to our society, we have established Noble Apex Charity Fund and the Noble Apex Charity Ambassadors team. The Charity Fund is aimed to provide useful financial knowledge to the public, hence improving the quality of life; and to offer voluntary services as per request and cooperate with non-profit organizations to provide people in need with necessary resources. Graphene, a kind of new material with singular flake structure composed of carbon atoms, is one of the best conductive materials in the world. The anode material of lithium ion battery made by graphene is able to significantly increase the energy storage capacity and shorten charging time of the battery, thus effectively resolving the bottleneck problem of applying lead-acid battery and traditional lithium ion battery to electric vehicles.
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On one hand, individual employees’ needs can still be catered, and on the other hands, negative effects can be minimized. The modelling of image histograms by a general parametric family of statistical distributions plays an important role in many applications such as scene analysis, image editing and medical imaging. Many studies have shown that the histogram of image variations is symmetrical about zero and has a sharp peak at zero. This phenomenon motivates the use of a parametric family of known distributions such as Generalised Gaussian Density to fit the observed histogram. The GGD model has been used by various previous works as a model for the distribution of high frequency coefficients and applied successfully to different areas such as content-based image retrieval and texture classification.
To research this, a conceptual model is developed and proposed to be tested with a survey study in Hong Kong. The findings would contribute not only to the compact city of Hong Kong, but also in a global context of increasing urban intensification. One typical approach to university education is to engage in academic discourses in which exchange of opinions and construction of knowledge take place. This could be challenging for undergraduates, especially learners of English as a foreign language , who have to learn about the conventions and practices of their discourse communities. While research wealth generators review on oral academic discourse socialisation has been conducted recently, most of these studies focused on non-native speakers in English-speaking countries, where more opportunities for scaffolding were provided by their native-speaking peers, compared to that in EFL contexts. Regarding preparation of ESL university students through courses on English for academic purposes , although there has been a considerable amount of research on EAP courses, little is still known about how EFL students are socialized into oral academic discourses and the relationship with EAP course design and activities.
Personal Data (privacy) Policy
This research thus explores a timely and important topic, one that pertains to the many online consumer forums that are accessible to reviewers and audience worldwide. In particular, it is of high theoretical and practical interest to investigate how globally accessible forums might induce different patterns of WOM behavior across cultures. Through controlled experiments and verbatim analysis of online reviews, this research will yield novel theoretical insights into cross-cultural consumer behavior and will empower practitioners to manage consumer-generated content across cultures. The underdeveloped political and economic structures inherited across post-colonial Africa created a domestic impetus for ISI. Marxist historians such as Walter Rodney contend that the gross underdevelopment in social services were a direct result of colonial economic strategy, which had to be abandoned to generate sustainable development. Rene Dumont supported that observation and argued that African states were administratively overburdened as a result of colonialism. The initial, unchanged conditions created discontent in states such as Ghana and Tanzania during the early 1960s over the fall in wages and employment opportunities.
With global business and improving standard of living, the aviation industry performance has significant contribution to the economy of a city. Hong Kong is such a role model; she has risen to the top 9th GDP per capita in the world. The airport has been ranked the top 5 in world’s best airport, the 10th world’s busiest airports by passenger traffic and number 1 by cargo traffic in 2013. However, with the rapid growth of Mainland China and Asian Countries, it is alarmed that HK will be “marginalized” in the near future. To maintain HK’s competitiveness, effective strategies must be adopted to uphold her strategic hub position in air industry. The proposal has attracted debates on airport’s positioning, strategic relationships among other Asian international airports, airlines and, passenger and cargo demand trends, etc. All these issues are inter-related and affected by many external factors, such as economic development, demographic and infrastructure developments of surrounding cities. Following the marketing literature, the round number bias in price setting also motivates consumers to buy by means of increasing their purchase intention. Similarly, investors purchase intention might be enhanced if they perceive a price drop from the round number threshold.
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The Group has clearly clarified the driving department for the management of scientific research and production with enhanced management planning. Through special project plan and deployment manoeuvring, orderly batch production of wind turbines was ensured under the guidance of the plans. The management procedure was reorganized with http://www.gamblingcommission.gov.uk/home.aspx clear-cut definition of responsibilities and duties between different departments. Thus we can achieve efficient operation of personnel movement, logistics, cash flows and information flows in the various processes of sales, planning, design, production, purchasing and finance, as well as effective closed-loop management and control.
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The qualitative study of the mixed method research involves conducting in-depth interviews with 20 female adults who reported CSA experience. Participants of the interviews would be recruited through referrals from NGOs which provide services for female adult survivors; and through convenience sampling by posting recruitment note on campus, in church, in Facebook, and in emails. Semi-structured interview guide would be used to conduct the in-depth interview, which lasts for about 2-3 hours. The interviews would be recorded, transcribed, and analyzed by Fraser’s method of narrative https://www.iagr.org/ analysis. Results of the qualitative study would be integrated with that of the quantitative study. At present, research studies on organizational effort in handling turnover problems and in retaining social workers have been lacking in Mainland China. The high social worker turnover is caused by the low social status and poor professional identity of social workers, poor management in social work organizations, and an imperfect social welfare system. Organizational career management in social work agencies, however, remains a significant yet little understood area.
The energy storage device of graphene is characterized by extra-long recycling life and high current during the process of charging and discharging, therefore there is huge market room of graphene-based new battery anode material and super capacitor under the research and development. Currently, the above research work has achieved certain stage results, and industrial production of the establishing project will commence after substantive results have been achieved later this year. The Group continued to give full play to the advantages of technology, quality and service of CASC directdrive wind turbines. On this basis, the Group capitalised on its products’ leading edge and achieved cost control by adopting the strategy of technology advancement and batch production through research and development, thereby achieving high supply chain performance and enhanced cost effectiveness to proactively address challenges.
In the piecewise linear approach, we will apply the multi-objective simplex method and Benson’s outer approximation algorithm to devise an effective algorithm to obtain the set of all Pareto optimal solutions. We will also apply the proposed algorithms to obtain optimal sparse portfolio strategies and use the real data from the Hong Kong Stock Exchange for empirical analysis. In this study, we aim to demonstrate PDT efficiency and investigate the optimum PDT dose by using two NPC 3D cell culture model approaches. We propose to use the 3D cell culture model to mimic the normal physiological condition and tumor microenvironment. The use of 3D cell culture model could provide us a more accurate prediction, particularly on the effect of oxygen content and light delivery to PDT efficiency in solid tumor. Outcome measures include the tumor size and characteristics, mode of cell death, intracellular signal proteins and drug resistance protein expression at pre- and post-PDT treatments.
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Cost-effective electricity made by wind drones could even provide the basis for the clean synthetic fuels of the future. Second, it’s time for our private sector to put funding into renewable energy and energy efficiency development. Globally, there are more new investments in renewable energies such as wind and solar than there are in coal, gas and nuclear combined. They are effectively winning against these dirty energy sources, because governments around the world realise the importance of supporting safe, low-carbon energy. The International Air Transport Association Millennium Asia and Pacific Regional Technical Conference is held in Hong Kong for three days starting from today . Over 120 representatives from airlines, international and airline organisations, the aviation industry and air traffic services providers attend the Conference. Mr Lam also briefed them on the work of CAD in other areas apart from the provision of ATC services. We intend to use your personal information collected by us for marketing and promotion of any products, services, facilities offered or provided by any member of Sino Inno Lab or which we consider you may have interested in. We may not so use your personal information unless we have received your consent to the intended use. If any customer does not want us to use his/her personal data for marketing or promotional purposes, please inform us via email to
Such information will be useful for teachers and other educators involved in teaching, designing and planning the language curriculum for typically developing children and children learning Cantonese as a second language. The developmental data will also be a useful reference for Hong Kong speech and language therapists in assessing children with pragmatic problems and difficulties. Furthermore, the database generated from this study will provide useful data for further research on Hong Kong children’s oral discourse development. In the last phase of reporting and dissemination, a teacher knowledge framework with components defined, a validated instrument and an HK MtEceK database will be produced, in addition to a dissemination seminar and at least one academic paper. In the long term, it may also contribute to policy-making through territory-wide profiling of teacher knowledge. There will be three separate studies and data will be collected from teams and companies in the Mainland China and Hong Kong. Based on the results, theoretical and practical implications can be provided to the scholars and practitioners. Specifically, we try to advance the understanding of servant leadership and i-deals from the perspective of social comparison. Practically, we can provide a better approach to the management people in order to offer i-deals in their companies.
A total of thirty participants will be recruited for the focus-group interviews occurring at five time points, with six participants in each focus group. All participants of the focus groups will be selected in terms of their genders, their relations with the family members who suffer from schizophrenia and the interventions that they received. Thematic analysis will be used to analyse the qualitative data and triangulate the findings of the quantitative assessment. The medium of instruction has been a bone of contention wealth generators review in Hong Kong since its colonial days. While it is evident from research that using the mother tongue as the medium of learning is far more effective than using English, the formulation of the MOI policy has always been motivated by political agenda and has to be understood in the broader social and political context. Despite the Hong Kong SAR government’s effort to promote the “biliterate and trilingual” language policy, most tertiary institutions today still adopt English as the medium of instruction.
- The first issue is the preprocess of short text which is prevalent in social networks.
- The third issue is that emotion perception is very personal and could vary from one person to another, that is, different users may have different attentions, perspectives or abilities when labeling documents emotionally.
- Under the Air Pollution Control Ordinance, carbon dioxide is not even considered a pollutant, even though it is widely agreed that ever-escalating carbon dioxide emissions are one of the largest threats to our planet and our city.
- If our electricity market is not going to change, there is no chance for us to stop climate change.
- The fourth issue is that the sentiment embedded in social networks often has intrinsic dynamics.
- Due to the fact that it is hard to control the authenticity and quality on the social network, spotting potentially malicious users and detecting noisy labels are critical to sentiment analysis.
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A triangulation of quantitative and qualitative data from multiple sources will be conducted. The findings of the study will provide pedagogical implications for the design of EAP courses on the development of speaking skills in EFL/ ESL contexts. The performance of an airport is affected by the global air transport network evolution, as well as the regional economic and social developments. To fully dissect the interrelationship between various airports and cities, passenger and cargo flows, https://www.iagr.org/ a comprehensive study on the air network is required. They were mainly studying the effects of pre-determined strategies or factors on either passenger or cargo volumes, by assuming all other variables independent. In this study, we will apply new research methodologies – network regression and data mining – to identify the, possibly hidden, relationships between airports based on the global passenger and cargo traffic volumes, among 5000 airports by routes, in the past 10 years.